Tnik^tm1Grnt
Targeted Allele Detail

Summary

• Symbol: Tnik^tm1Grnt
• Name: TRAF2 and NCK interacting kinase; targeted mutation 1, Seth G N Grant
• MGI ID: MGI:5461352
• Gene: Tnik Location: Chr3:28317362-28724734 bp, + strand Genetic Position: Chr3, 11.92 cM
• Alliance: Tnik^tm1Grnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190924
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ and a floxed neo cassette was inserted into the kinase domain. Western blot analysis confirmed the absence of protein expression in the hippocampus. (J:190924)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnik Mutation: 74 strains or lines available

References

• Original: J:190924 Coba MP, et al., TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J Neurosci. 2012 Oct 3;32(40):13987-99
• All: 1 reference(s)