Fcmr^tm1Ohno
Targeted Allele Detail

Summary

• Symbol: Fcmr^tm1Ohno
• Name: Fc fragment of IgM receptor; targeted mutation 1, Hiroshi Ohno
• MGI ID: MGI:5450845
• Gene: Fcmr Location: Chr1:130793514-130808528 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband E4
• Alliance: Fcmr^tm1Ohno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190117
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2-4 were replaced with a neo cassette via homologous recombination. (J:190113, J:190117)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcmr Mutation: 26 strains or lines available

References

• Original: J:190117 Honjo K, et al., Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcmuR). Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15882-7
• All: 3 reference(s)