Six1^tm2.2Mair
Targeted Allele Detail

Summary

• Symbol: Six1^tm2.2Mair
• Name: sine oculis-related homeobox 1; targeted mutation 2.2, Pascal Maire
• MGI ID: MGI:5449829
• Synonyms: Six1^delta
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm2.2Mair page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190460
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination of Six1^tm2.1Mair, lacking the neo cassette, removed exon 1. The dsRed gene is left intact. Immunohistochemistry confirmed the absence of protein expression in E12.5 embryonic myofibers. (J:190460)

Generation of the conditional Six1^tm2.1Mair and delta Six1^tm2.2Mair alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 18 strains or lines available

References

• Original: J:190460 Le Grand F, et al., Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012 Sep 3;198(5):815-32
• All: 2 reference(s)