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Gt(ROSA)26Sortm3(CAG-COP4*C128A/mCherry)Imayo
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm3(CAG-COP4*C128A/mCherry)Imayo
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Itaru Imayoshi
MGI ID: MGI:5449176
Synonyms: Gt(ROSA)26Sortm1(CAG-ChR2/mCherry)Imayo, R26-CAG-LF-ChR2(C128A)-mCherry
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm3(CAG-COP4*C128A/mCherry)Imayo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190172
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsThe transgene targeted ot the locus contains a splice acceptor flanked puro cassette, CAG promoter, floxed stop cassette, FRT-flanked stop cassette, the channelrhodopsin-2 from the green alga Chlamydomonas reinhardtii modified to contain a C128A substitution (COP4*C128A), and a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE). (J:190172)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  997 strains or lines available
References
Original:  J:190172 Imayoshi I, et al., Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0. Neurosci Res. 2013 Jan;75(1):53-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/24/2024
MGI 6.24
The Jackson Laboratory