Mir378atm1.1Eno
Targeted Allele Detail
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Symbol: |
Mir378atm1.1Eno |
Name: |
microRNA 378a; targeted mutation 1.1, Eric N Olson |
MGI ID: |
MGI:5448834 |
Gene: |
Mir378a Location: Chr18:61530906-61530971 bp, - strand Genetic Position: Chr18, 34.62 cM
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Alliance: |
Mir378atm1.1Eno page
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Mir378atm1.1Eno/Mir378atm1.1Eno mice are resistant to high-fat diet-induced obesity
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:190154
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The microRNA sequence was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. qRT-PCR confirmed the absence of transcript expression. Western blot analysis confirmed normal protein expression of the host gene.
(J:190154)
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Generation of the Mir378atm1.1Eno allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mir378a Mutation: |
4 strains or lines available
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Original: |
J:190154 Carrer M, et al., Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15330-5 |
All: |
6 reference(s) |
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