Vav1^tm4Tyb
Targeted Allele Detail

Summary

• Symbol: Vav1^tm4Tyb
• Name: vav 1 oncogene; targeted mutation 4, Victor Tybulewicz
• MGI ID: MGI:5447927
• Synonyms: Vav1^AA
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^tm4Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190087
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Mutations were inserted in exon 10 which caused Leu334Ala and Lys335Ala amino acid residue changes. In addition,k a floxed neo cassette was inserted in intron 9. Subsequent cre mediated excision removed the neo cassette. (J:190087)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 58 strains or lines available

References

• Original: J:190087 Saveliev A, et al., Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal. 2009;2(101):ra83
• All: 3 reference(s)