Siglec1^tm2.1Croc
Targeted Allele Detail

Summary

• Symbol: Siglec1^tm2.1Croc
• Name: sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 2.1, Paul R Crocker
• MGI ID: MGI:5447769
• Synonyms: Sn^W2QR97A
• Gene: Siglec1 Location: Chr2:130911140-130928685 bp, - strand Genetic Position: Chr2, 63.26 cM, cytoband F-H1
• Alliance: Siglec1^tm2.1Croc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189854
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with one in which nucleotide substitutions result in the amino acid substitutions of glutamine for tryptophan at position 2 (W2Q) and alanine for arginine at position 97 (R97A). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 2. (J:189854)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglec1 Mutation: 82 strains or lines available

References

• Original: J:189854 Klaas M, et al., Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni. J Immunol. 2012 Sep 1;189(5):2414-22
• All: 2 reference(s)