Trp53cor1^tm1.1Tyj
Targeted Allele Detail

Summary

• Symbol: Trp53cor1^tm1.1Tyj
• Name: tumor protein p53 pathway corepressor 1; targeted mutation 1.1, Tyler Jacks
• MGI ID: MGI:5447369
• Synonyms: LincRNA-p21^f
• Gene: Trp53cor1 Location: Chr17:29276448-29298100 bp, - strand Genetic Position: Chr17, 15.04 cM
• Alliance: Trp53cor1^tm1.1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215235
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The promoter region and first exon, which includes the Trp53 response element (p53RE), are flanked by loxP sites and an FRT-Neo-FRT drug selection cassette is placed downstream of exon 1, just inside the floxed region. Flp-mediated recombination removed the neo cassette. (J:215235)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53cor1 Mutation: 31 strains or lines available

References

• Original: J:215235 Dimitrova N, et al., LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Mol Cell. 2014 Jun 5;54(5):777-90
• All: 1 reference(s)