Tg(Sim1-cre)#Lowl
Transgene Detail

Summary

• Symbol: Tg(Sim1-cre)#Lowl
• Name: transgene insertion, Bradford B Lowell
• MGI ID: MGI:5447031
• Synonyms: Sim1-cre
• Transgene: Tg(Sim1-cre)#Lowl Location: unknown
• Alliance: Tg(Sim1-cre)#Lowl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Sim1-cre)#Lowl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Sim1

• Mutation details: The cre ATG was inserted via recombineering techniques, into the Sim1 ATG site of a BAC containing 137.1 kb of genomic C57BL/6 Sim1 sequences up to and including exon 8. The inserted cre sequence deleted the first 31 bp of the Sim1 gene. Lines 1 and 2 were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:115192)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sim1 (species not specified) Summary of all recombinase alleles driven by Sim1. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189194 Chen M, et al., Gsalpha deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsalpha mutations. Endocrinology. 2012 Sep;153(9):4256-65
• All: 31 reference(s)