Kmt2a^{tm1(MLL1/ERT)Divo}
Targeted Allele Detail

Summary

• Symbol: Kmt2a^{tm1(MLL1/ERT)Divo}
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Vladimir Divoky
• MGI ID: MGI:5447014
• Synonyms: Mll-ENL-ERtm/Neo^floxed
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^{tm1(MLL1/ERT)Divo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189329
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Kmt2a^{tm1(MLL1/ERT)Divo} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KMT2A (4297)

  Kmt2a

  (MGI:96995)

• Mutation details: Exons 12 through 36 were replaced with a construct containing the human cDNA, a linker sequence, mutated estrogen-binding domain of the estrogen receptor (ERT or ERtm), polyadenylation sequence and floxed neo cassette. The predicted fusion product function depends on tamoxifen treatment. (J:189329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 137 strains or lines available

References

• Original: J:189329 Takacova S, et al., DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo. Cancer Cell. 2012 Apr 17;21(4):517-31
• All: 1 reference(s)