Tpcn1^tm1Dren
Targeted Allele Detail

Summary

• Symbol: Tpcn1^tm1Dren
• Name: two pore channel 1; targeted mutation 1, Dejian Ren
• MGI ID: MGI:5446044
• Gene: Tpcn1 Location: Chr5:120672222-120726731 bp, - strand Genetic Position: Chr5, 60.63 cM
• Alliance: Tpcn1^tm1Dren page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189070
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The exon containing the translation start site was floxed via homologous recombination. (J:189070)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpcn1 Mutation: 72 strains or lines available

References

• Original: J:189070 Wang X, et al., TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012 Oct 12;151(2):372-83
• All: 1 reference(s)