Mcam^tm1Yanx
Targeted Allele Detail

Summary

• Symbol: Mcam^tm1Yanx
• Name: melanoma cell adhesion molecule; targeted mutation 1, Xiyun Yan
• MGI ID: MGI:5445382
• Synonyms: CD146^floxed
• Gene: Mcam Location: Chr9:44045946-44054024 bp, + strand Genetic Position: Chr9, 24.68 cM
• Alliance: Mcam^tm1Yanx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189203
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. (J:210618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcam Mutation: 34 strains or lines available

References

• Original: J:189203 Jiang T, et al., CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood. 2012 Sep 13;120(11):2330-9
• All: 8 reference(s)