Hsd11b1^tm1Ggla
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1Ggla
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Gareth Lavery
• MGI ID: MGI:5444438
• Synonyms: 11beta-HSD1^fl
• Gene: Hsd11b1 Location: Chr1:192903948-192946353 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1Ggla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189132
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. (J:189132)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 27 strains or lines available

References

• Original: J:189132 Semjonous NM, et al., Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology. 2011 Jan;152(1):93-102
• All: 8 reference(s)