Erg^tm1Poet
Targeted Allele Detail

Summary

• Symbol: Erg^tm1Poet
• Name: ETS transcription factor; targeted mutation 1, Peter Oettgen
• MGI ID: MGI:5443836
• Synonyms: Erg^deltaEx3
• Gene: Erg Location: Chr16:95160028-95387452 bp, - strand Genetic Position: Chr16, 56.04 cM
• Alliance: Erg^tm1Poet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188920
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a lacZ-neo cassette via homologous recombination. This mutation should abolish expression of isoforms 1 - 4 while retaining expression of isoforms 5 - 7. Strong LacZ expression is seen only in articular cartilage. (J:188920)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erg Mutation: 27 strains or lines available

References

• Original: J:188920 Vijayaraj P, et al., Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov;139(21):3973-85
• All: 2 reference(s)