Tg(Adam12-tTA,-HBEGF)1Lpe
Transgene Detail

Summary

• Symbol: Tg(Adam12-tTA,-HBEGF)1Lpe
• Name: transgene insertion 1, Lucie Peduto
• MGI ID: MGI:5442697
• Synonyms: Adam12-tTA-ires-Dtr^TG, M12-tTA
• Transgene: Tg(Adam12-tTA,-HBEGF)1Lpe Location: unknown
• Alliance: Tg(Adam12-tTA,-HBEGF)1Lpe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Transactivator)
• Mutation: Insertion
• Tg(Adam12-tTA,-HBEGF)1Lpe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A tTA-ires-HBEGF (tTA-ires-DTR) coding sequence, including a polyA sequence was inserted into exon 1 of the Adam12 gene in a 200 kb BAC by homologous recombination. The sequence replaced the endogenous ATG translation start codon. The modified BAC was used to generate transgenic founders. Line information is not available. (J:188912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:188912 Dulauroy S, et al., Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat Med. 2012 Aug;18(8):1262-70
• All: 3 reference(s)