Rev3l^tm1.1Kunk
Targeted Allele Detail

Summary

• Symbol: Rev3l^tm1.1Kunk
• Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1.1, Thomas A Kunkel
• MGI ID: MGI:5442607
• Synonyms: Rev3L2610F
• Gene: Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
• Alliance: Rev3l^tm1.1Kunk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188723
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 25 was replaced with one in which nucleotide substitutions (CTA to TTC) result in the amino acid substitution of phenylalanine for leucine at postion 2610 (L2610F). A floxed neo cassette inserted downstream of the modified exon 25 was removed by cre-mediated recombination. (J:188723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rev3l Mutation: 120 strains or lines available

References

• Original: J:188723 Daly J, et al., Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase zeta activity. J Immunol. 2012 Jun 1;188(11):5528-37
• All: 1 reference(s)