Rhbdd1^tm1.1Mfm
Targeted Allele Detail

Summary

• Symbol: Rhbdd1^tm1.1Mfm
• Name: rhomboid domain containing 1; targeted mutation 1.1, Matthew Freeman
• MGI ID: MGI:5442518
• Synonyms: R4 ko, RHBDL4 KO
• Gene: Rhbdd1 Location: Chr1:82294178-82423087 bp, + strand Genetic Position: Chr1, 42.08 cM, cytoband C5
• Alliance: Rhbdd1^tm1.1Mfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325547
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon (exon 2) was flanked by loxP sites and a neomycin resistance cassette was also inserted. Cre-mediated recombination removed the first coding exon and the neomycin cassette. (J:188911, J:325547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhbdd1 Mutation: 18 strains or lines available

References

• Original: J:325547 Lastun VL, et al., The mammalian rhomboid protein RHBDL4 protects against endoplasmic reticulum stress by regulating the morphology and distribution of ER sheets. J Biol Chem. 2022 Apr 15;298(6):101935
• All: 4 reference(s)