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Transgene Detail
Symbol: Tg(Vav1-JAK2*V617F)AZjz
Name: transgene insertion A, Zhizhuang Joe Zhao
MGI ID: MGI:5441310
Synonyms: JAK2V617F, JAK2V617F tg
Transgene: Tg(Vav1-JAK2*V617F)AZjz  Location: unknown  
Alliance: Tg(Vav1-JAK2*V617F)AZjz page
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Vav1-JAK2*V617F)AZjz expresses 1 gene
Mutation detailsThis transgene consists of the entire coding region of human JAK2 with the V617F mutation and the 3' noncoding region under the control of the Vav1 promoter. Line A is expressed in hematopoietic tissues, including the thymus, bone marrow, spleen, peripheral blood, and lymph nodes, but not in various nonhematopoietic tissues except for the lung. The gene copy number for line A is 13 +/- 1.4 based on real-time PCR. (J:135993)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:135993 Xing S, et al., Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 May 15;111(10):5109-17
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory