Lrp4^tm1.1Line
Targeted Allele Detail

Summary

• Symbol: Lrp4^tm1.1Line
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 1.1, Lin Mei
• MGI ID: MGI:5440737
• Synonyms: LRP4^f, LRP4^loxP
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^tm1.1Line page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188352
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:188352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 97 strains or lines available

References

• Original: J:188352 Wu H, et al., Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron. 2012 Jul 12;75(1):94-107
• All: 11 reference(s)