Bmal1^tm1.1Ljm
Targeted Allele Detail

Summary

• Symbol: Bmal1^tm1.1Ljm
• Name: basic helix-loop-helix ARNT like 1; targeted mutation 1.1, Louis J Muglia
• MGI ID: MGI:5440061
• Synonyms: Bmal1 flox
• Gene: Bmal1 Location: Chr7:112806672-112913333 bp, + strand Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
• Alliance: Bmal1^tm1.1Ljm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188253
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an Frt-flanked neo selection cassette as well as a second loxP site were placed downstream of exon 4 of Arntl in a targeting vector. Homologous recombination in ES cells produced a conditional allele of Arntl. The neo was deleted by mating these mutants with transgenic mice expressing flp recombinase. (J:188253)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmal1 Mutation: 137 strains or lines available

References

• Original: J:188253 Ratajczak CK, et al., Generation of myometrium-specific Bmal1 knockout mice for parturition analysis. Reprod Fertil Dev. 2012;24(5):759-67
• All: 1 reference(s)