Ap1ar^tm1.1Vha
Targeted Allele Detail

Summary

• Symbol: Ap1ar^tm1.1Vha
• Name: adaptor-related protein complex 1 associated regulatory protein; targeted mutation 1.1, Volker Haucke
• MGI ID: MGI:5439984
• Synonyms: Gadkin-deficient
• Gene: Ap1ar Location: Chr3:127600656-127631148 bp, - strand Genetic Position: Chr3, 56.54 cM
• Alliance: Ap1ar^tm1.1Vha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185589
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin selection cassette replaced part of exone 1 including the ATG start site. Subsequent cre expression excised the selection cassette. (J:185589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap1ar Mutation: 15 strains or lines available

References

• Original: J:185589 Maritzen T, et al., Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7
• All: 3 reference(s)