Prdm1^tm3(icre)Rob
Targeted Allele Detail

Summary

• Symbol: Prdm1^tm3(icre)Rob
• Name: PR domain containing 1, with ZNF domain; targeted mutation 3, Elizabeth J Robertson
• MGI ID: MGI:5439582
• Synonyms: Prdm1-Cre-IRES-nlacZ, Prdm1^Cre.LacZ
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^tm3(icre)Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Prdm1^tm3(icre)Rob expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prdm1 (MGI:99655)

• Mutation details: A construct containing a cassette encoding a codon optimized cre, IRES and nuclear localized lacZ and an FRT flanked neo cassette was inserted into the first coding exon via homologous recombination. At E7.5, E9.5, E10.5 and in postnatal mice, lacZ activity mirrors endogenous gene expression. (J:187742)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prdm1 (mouse) Summary of all recombinase alleles driven by Prdm1. Comparative matrix view of recombinase activities Alliance mouse Prdm1 gene page

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 64 strains or lines available

References

• Original: J:187742 Mould A, et al., Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev. 2012 Sep 15;26(18):2063-74
• All: 2 reference(s)