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Targeted Allele Detail
Symbol: Kpna1tm1.1Yyo
Name: karyopherin subunit alpha 1; targeted mutation 1.1, Yoshihiro Yoneda
MGI ID: MGI:5439492
Synonyms: Impalpha5flox
Gene: Kpna1  Location: Chr16:35803693-35859479 bp, + strand  Genetic Position: Chr16, 25.43 cM, cytoband B4-B5
Alliance: Kpna1tm1.1Yyo page
Germline Transmission:  Earliest citation of germline transmission: J:188099
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:188099)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kpna1 Mutation:  67 strains or lines available
Original:  J:188099 Moriyama T, et al., Targeted disruption of one of the importin alpha family members leads to female functional incompetence in delivery. FEBS J. 2011 May;278(9):1561-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory