Defb41^{tm1(icre)Psip}
Targeted Allele Detail

Summary

• Symbol: Defb41^{tm1(icre)Psip}
• Name: defensin beta 41; targeted mutation 1, Petra Sipila
• MGI ID: MGI:5439010
• Synonyms: Defb^iCre
• Gene: Defb41 Location: Chr1:18321204-18335362 bp, - strand Genetic Position: Chr1, 5.7 cM, cytoband A4
• Alliance: Defb41^{tm1(icre)Psip} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187838
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Defb41^{tm1(icre)Psip} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Defb41 (MGI:1924923)

• Mutation details: cDNA encoding icr (improved cre) was inserted into the translation initiation site of the defensin beta 41 (Defb41) gene. icre is expressed in the proximal epididymis epithelium (in the initial segment, IS, and caput, CAP, of the epididymis). Full characterization of knockin mice will be published later. (J:187838)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Defb41 (mouse) Summary of all recombinase alleles driven by Defb41. Alliance mouse Defb41 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Defb41 Mutation: 6 strains or lines available

References

• Original: J:187838 Bjorkgren I, et al., Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One. 2012;7(6):e38457
• All: 5 reference(s)