Il34tm1b(EUCOMM)Wtsi
Targeted Allele Detail
|
Symbol: |
Il34tm1b(EUCOMM)Wtsi |
Name: |
interleukin 34; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5438224 |
Synonyms: |
Il34LacZ |
Gene: |
Il34 Location: Chr8:111468461-111532556 bp, - strand Genetic Position: Chr8, 57.68 cM
|
Alliance: |
Il34tm1b(EUCOMM)Wtsi page
|
IMPC: |
Il34 gene page |
|
Mutant Cell Line: |
EPD0146_4_D03 |
Germline Transmission: |
Earliest citation of germline transmission:
J:187643
|
Parent Cell Line: |
JM8.N4 (ES Cell)
|
Strain of Origin: |
C57BL/6N
|
Project Collection: |
EUCOMM
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutations: |
|
Insertion, Intragenic deletion
Vector: L1L2_Bact_P
|
|
|
Mutation details: Cre-mediated recombination of Il34tm1a(EUCOMM)Wtsi removed exons 3 through 5. The FRT-flanked lacZ/neo cassette upstream of exon 3 remains intact. Immunohistochemistry confirmed the absence of protein expression in the brain and skin.
(J:187643)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Il34 Mutation: |
22 strains or lines available
|
|
Original: |
J:187643 Wang Y, et al., IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol. 2012;13(8):753-60 |
All: |
11 reference(s) |
|