Igh-7^tm1.2Cdca
Targeted Allele Detail

Summary

• Symbol: Igh-7^tm1.2Cdca
• Name: immunoglobulin heavy chain 7 (heavy chain of IgE); targeted mutation 1.2, Christopher D C Allen
• MGI ID: MGI:5437215
• Synonyms: Verigem
• Gene: Igh-7 Location: Chr12:113228142-113241336 bp Genetic Position: Chr12, Syntenic
• Alliance: Igh-7^tm1.2Cdca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187336
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An FRT-flanked dTomato cassette was inserted downstream of exon Cepsilon 4. A T2A-Venus with a 3' lox2271-floxed neo cassette was inserted downstream of exon M2. Flp-mediated recombination removed the dTomato cassette. Cre-mediated recombination removed the neo cassette. (J:187336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-7 Mutation: 2 strains or lines available

References

• Original: J:187336 Yang Z, et al., Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity. 2012 May 25;36(5):857-72
• All: 3 reference(s)