Ptpn2^tm2.1Ttig
Targeted Allele Detail

Summary

• Symbol: Ptpn2^tm2.1Ttig
• Name: protein tyrosine phosphatase, non-receptor type 2; targeted mutation 2.1, Tony Tiganis
• MGI ID: MGI:5436249
• Synonyms: Ptpn2^ex2-
• Gene: Ptpn2 Location: Chr18:67798581-67857665 bp, - strand Genetic Position: Chr18, 40.06 cM
• Alliance: Ptpn2^tm2.1Ttig page

Runtiness of Ptpn2^tm1Mtr/Ptpn2^tm1Mtr and Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186843
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the pgk-neo cassette. Western blot analysis confirmed the absence of full length protein in tissues from homozygous mice. (J:186843)

Generation of the Ptpn2^tm2.1Ttig allele

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn2 Mutation: 42 strains or lines available

References

• Original: J:186843 Wiede F, et al., Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. PLoS One. 2012;7(5):e36703
• All: 4 reference(s)