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Ptpn2tm2.1Ttig
Targeted Allele Detail
Summary
Symbol: Ptpn2tm2.1Ttig
Name: protein tyrosine phosphatase, non-receptor type 2; targeted mutation 2.1, Tony Tiganis
MGI ID: MGI:5436249
Synonyms: Ptpn2ex2-
Gene: Ptpn2  Location: Chr18:67798581-67857665 bp, - strand  Genetic Position: Chr18, 40.06 cM
Alliance: Ptpn2tm2.1Ttig page
Runtiness of Ptpn2tm1Mtr/Ptpn2tm1Mtr and Ptpn2tm2.1Ttig/Ptpn2tm2.1Ttig mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186843
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the pgk-neo cassette. Western blot analysis confirmed the absence of full length protein in tissues from homozygous mice. (J:186843)
Generation of the Ptpn2tm2.1Ttig allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn2 Mutation:  43 strains or lines available
References
Original:  J:186843 Wiede F, et al., Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. PLoS One. 2012;7(5):e36703
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory