Sp3^tm3.1Sus
Targeted Allele Detail

Summary

• Symbol: Sp3^tm3.1Sus
• Name: trans-acting transcription factor 3; targeted mutation 3.1, Guntram Suske
• MGI ID: MGI:5435925
• Gene: Sp3 Location: Chr2:72766774-72810790 bp, - strand Genetic Position: Chr2, 43.35 cM, cytoband C3
• Alliance: Sp3^tm3.1Sus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186945
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4, encoding the major transactivation domain, was flanked by LoxP sites and Ires-lacZ-neo flanked by FRT sites. Flp-mediated recombination removed the neo cassette. (personal communication)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp3 Mutation: 64 strains or lines available

References

• Original: J:186945 Ingram RM, et al., Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5. Exp Hematol. 2011 Jul;39(7):730-40.e1-2
• All: 5 reference(s)