Shank3^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Shank3^tm1Geno
• Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 1, Genoway
• MGI ID: MGI:5435699
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186719
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 11 via homologous recombination. (J:186719)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 88 strains or lines available

References

• Original: J:186719 Schmeisser MJ, et al., Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Jun 14;486(7402):256-60
• All: 2 reference(s)