Gt(ROSA)26Sor^{tm1(PGK1-cre)Ozg}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(PGK1-cre)Ozg}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ozgene
• MGI ID: MGI:5435692
• Synonyms: OzCre, OzCre deleter
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(PGK1-cre)Ozg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197875
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(PGK1-cre)Ozg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	PGK1

• Mutation details: A PGK-cre recombinase transgene, followed by a FRT site-flanked neomycin resistance cassette, was inserted into intron 1-2 of the ROSA26 locus. The construct was electroporated into Bruce4 ES cells. Chimeras were backcrossed to C57BL/6J mice and the line was maintained on the B6 background. (J:197875)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	PGK1 (species not specified) Summary of all recombinase alleles driven by PGK1.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:197875 Nagura H, et al., Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Mol Brain. 2012;5:43
• All: 15 reference(s)