Mir133b^tm1.2Gfng
Targeted Allele Detail

Summary

• Symbol: Mir133b^tm1.2Gfng
• Name: microRNA 133b; targeted mutation 1.2, Guoping Feng
• MGI ID: MGI:5433550
• Synonyms: miR-133b KO
• Gene: Mir133b Location: Chr1:20752993-20753111 bp, + strand Genetic Position: Chr1, 6.41 cM
• Alliance: Mir133b^tm1.2Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186618
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the stem loop sequence and a FRT flanked neo cassette and loxP site were inserted downstream of the stem loop sequence. Recombinase mediated recombination removed the neo cassette and the entire stem loop structure. (J:186618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir133b Mutation: 0 strains or lines available

References

• Original: J:186618 Heyer MP, et al., Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice. J Neurosci. 2012 Aug 8;32(32):10887-10894
• All: 2 reference(s)