Tg(CMV-GFP,-BBS4)4T25Vcs
Transgene Detail

Summary

• Symbol: Tg(CMV-GFP,-BBS4)4T25Vcs
• Name: transgene insertion 4T25, Val C Sheffield
• MGI ID: MGI:5432908
• Synonyms: Bbs4-pLAP, LAP-BBS4
• Transgene: Tg(CMV-GFP,-BBS4)4T25Vcs Location: unknown
• Alliance: Tg(CMV-GFP,-BBS4)4T25Vcs page

Transgene origin

• Strain of Origin: C57BL/6J x SJL/J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-GFP,-BBS4)4T25Vcs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BBS4 (585)

  Bbs4	(MGI:2143311)

• Mutation details: Human BBS4 and a LAP tag (GFP followed by a cleavage site for Tobacco Etch Virus (TEV) protease and an S-tag) were placed under the control of cytomegalovirus (CMV) immediate early (IE94) promoter in a transgenic vector. Three lines were generated with the highest expression level in line 4T25. (J:177990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:177990 Seo S, et al., A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened. PLoS Genet. 2011 Nov;7(11):e1002358
• All: 1 reference(s)