Tg(tetO-GLI1)10Rup
Transgene Detail

Summary

• Symbol: Tg(tetO-GLI1)10Rup
• Name: transgene insertion 10, J Ruppert
• MGI ID: MGI:5432196
• Synonyms: TRE-GLi1
• Transgene: Tg(tetO-GLI1)10Rup Location: unknown
• Alliance: Tg(tetO-GLI1)10Rup page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-GLI1)10Rup expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GLI1 (2735)

  Gli1	(MGI:95727)

• Mutation details: The 5.7 kB transgenic construct contains a tetracycline responsive element (TRE or tetO), the minimal human cytomegalovirus promoter, and an HA-tagged wildtype human GLI1, GLI1-Kruppel family member GLI1. (J:186380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:186380 Li X, et al., Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene. 2006 Jan 26;25(4):609-21
• All: 1 reference(s)