Trp53^tm2.1Kasa
Targeted Allele Detail

Summary

• Symbol: Trp53^tm2.1Kasa
• Name: transformation related protein 53; targeted mutation 2.1, Kanaga Sabapathy
• MGI ID: MGI:5432141
• Synonyms: p53^S312A
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm2.1Kasa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186335
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution (TCT-to-GCG) result in the amino acid substitution of serine with alanine at position 312 (p.S312A). A loxP site flanked neomycin resistance gene cassette that was inserted was removed by Cre-mediated recombination. (J:186335)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:186335 Lee MK, et al., Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo. Cell Death Differ. 2011 Feb;18(2):214-21
• All: 1 reference(s)