Tg(tetO-LAMA5)1Jhm
Transgene Detail

Summary

• Symbol: Tg(tetO-LAMA5)1Jhm
• Name: transgene insertion 1, Jeffrey H Miner
• MGI ID: MGI:5431872
• Synonyms: tetO-LA5
• Transgene: Tg(tetO-LAMA5)1Jhm Location: unknown
• Alliance: Tg(tetO-LAMA5)1Jhm page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The full-length human laminin alpha5 (LA5; LAMA5) cDNA with a bovine growth hormone polyadenylation signal was placed under control of the tetracycline resistance-operon tetO (7 copies) and the CMV minimal promoter. The construct was microinjected into single-celled C57BL/6NTac embryos. 15 potential founders were obtained. 2 expressed the transgene in the expected pattern, and one of these was analyzed further. (J:185850)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:185850 Goldberg S, et al., Maintenance of glomerular filtration barrier integrity requires laminin alpha5. J Am Soc Nephrol. 2010 Apr;21(4):579-86
• All: 3 reference(s)