Neurog2^{tm1(icre/ERT2*)Ggc}
Targeted Allele Detail

Summary

• Symbol: Neurog2^{tm1(icre/ERT2*)Ggc}
• Name: neurogenin 2; targeted mutation 1, Giacomo Consalez
• MGI ID: MGI:5431772
• Synonyms: Neurog2^CreER, Neurog2::ER^T2iCreER^T2, Neurog2^{tm1(icre/ERT2*)Fro}
• Gene: Neurog2 Location: Chr3:127426784-127429280 bp, + strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Neurog2^{tm1(icre/ERT2*)Ggc} page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:185504
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Neurog2^{tm1(icre/ERT2*)Ggc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurog2 (MGI:109619)

• Mutation details: A targeting construct was generated by homologous recombination in a BAC containing the Neurog2 gene. An ERT2iCreERT2 sequence (icre/ERT2*; codon inproved cre fused in-frame N- and C-terminally with mutated human estrogen receptors) was inserted into exon 2 of Neurog2, replacing the entire coding sequence. The construct was electroporated into ES cells for homologous recombination. (J:185504)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog2 (mouse) Summary of all recombinase alleles driven by Neurog2. Alliance mouse Neurog2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurog2 Mutation: 18 strains or lines available

References

• Original: J:185504 Florio M, et al., Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development. Development. 2012 Jul;139(13):2308-20
• All: 6 reference(s)