b2b383Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b383Clo
• Name: Mutant line 383; Bench to Bassinet Program (B2B/CVDC), mutation 383 Cecilia Lo
• MGI ID: MGI:5431636
• Synonyms: Pink Panther
• Gene: b2b383Clo Location: unknown
• Alliance: b2b383Clo page

Mutant 383-006-NC exhibits right sided aortic arch

Show the 13 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b383Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiac defects: Right aortic arch, overriding aorta/double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), ventricular hypertrophy
Non-cardiac defects: Craniofacial defects - no mouth/nostril openings, no lower jaw/micrognathia, holoprosencephaly, anopthalmia/enopthalmia/micropthalmia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1100	Atrioventricular canal (endocardial cushion defect)
1300	Ventricular septal defect
1432	Overriding aortic valve
2720	Right aortic arch
3608	Left ventricular hypertrophy
3609	Right ventricular hypertrophy
4163	Micrognathia
4338	Holoprosencephaly
4877	Microphthalmia
0600	Double outlet right ventricle

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)