About   Help   FAQ
Tg(Msx3-icre)1/1Wdr
Transgene Detail
Summary
Symbol: Tg(Msx3-icre)1/1Wdr
Name: transgene insertion 1/1, William D Richardson
MGI ID: MGI:5430776
Synonyms: line 1/1, Msx3-cre, Msx3/iCre
Transgene: Tg(Msx3-icre)1/1Wdr  Location: unknown  
Alliance: Tg(Msx3-icre)1/1Wdr page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Msx3-icre)1/1Wdr expression driven by 1 gene
 
Mutation detailsA targeting vector was used to insert a codon improved cre recombinase (icre) and an Frt-flanked chloramphenicol selection cassette into exon 1 of the Msx3 locus in a phage artificial chromosome (PAC 402-G09) by homologous recombination. This resulted in fusing the icre sequence to the ATG of Msx3. The selection cassette was removed by induction of Flpe in EL250 cells, and the purified vector was used for pronuclear injection. 8 founders were obtained. Of these 2 were studied in more detail (1/1 and 3/2), displaying identical patterns of cre expression and GFP expression when crossed to ROSA-GFP reporter mice. Line 1/1 was used for derivation of animals for experimental study. (J:186011)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Msx3 (species not specified)
Summary of all recombinase alleles driven by Msx3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:186011 Fogarty MH, Fate-mapping the mouse neural tube by Cre-loxP transgenesis. PhD Thesis - University of London. 2006;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
09/24/2024
MGI 6.24
The Jackson Laboratory