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Transgene Detail
Symbol: Tg(Msx3-icre)1/1Wdr
Name: transgene insertion 1/1, William D Richardson
MGI ID: MGI:5430776
Synonyms: line 1/1, Msx3-cre, Msx3/iCre
Transgene: Tg(Msx3-icre)1/1Wdr  Location: unknown  
Alliance: Tg(Msx3-icre)1/1Wdr page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Tg(Msx3-icre)1/1Wdr expression driven by 1 gene
Mutation detailsA targeting vector was used to insert a codon improved cre recombinase (icre) and an Frt-flanked chloramphenicol selection cassette into exon 1 of the Msx3 locus in a phage artificial chromosome (PAC 402-G09) by homologous recombination. This resulted in fusing the icre sequence to the ATG of Msx3. The selection cassette was removed by induction of Flpe in EL250 cells, and the purified vector was used for pronuclear injection. 8 founders were obtained. Of these 2 were studied in more detail (1/1 and 3/2), displaying identical patterns of cre expression and GFP expression when crossed to ROSA-GFP reporter mice. Line 1/1 was used for derivation of animals for experimental study. (J:186011)
 Tissue activity of this recombinase allele
Driver: Msx3 (species not specified)
Summary of all recombinase alleles driven by Msx3.

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:186011 Fogarty MH, Fate-mapping the mouse neural tube by Cre-loxP transgenesis. PhD Thesis - University of London. 2006;
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory