Mir34a^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm1.1Kry
• Name: microRNA 34a; targeted mutation 1.1, Gerard Karsentry
• MGI ID: MGI:5427918
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm1.1Kry page

Increased bone mass in Mir34a^tm1.1Kry/Mir34a^tm1.1Kry Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185130
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of the microRNA. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the microRNA. Flp-mediated recombination removed the neo cassette and left the microRNA floxed. (J:185130)

Generation of the Mir34a^tm1.1Kry allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 12 strains or lines available

References

• Original: J:185130 Wei J, et al., miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21
• All: 1 reference(s)