Gbp5^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Gbp5^tm1Tigm
• Name: guanylate binding protein 5; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5426809
• Gene: Gbp5 Location: Chr3:142202695-142228105 bp, + strand Genetic Position: Chr3, 66.69 cM
• Alliance: Gbp5^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183942
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first and second coding exons were replaced with a lacZ/neo cassette. Western blot confirmed the absence of protein expression in bone marrow-derived macrophage. (J:183942)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbp5 Mutation: 37 strains or lines available

References

• Original: J:183942 Shenoy AR, et al., GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 2012 Apr 27;336(6080):481-5
• All: 1 reference(s)