Rr320^tm7.1Mkg
Targeted Allele Detail

Summary

• Symbol: Rr320^tm7.1Mkg
• Name: regulatory region 320; targeted mutation 7.1, Mark Groudine
• MGI ID: MGI:5426378
• Synonyms: deltaHS2-3, Hbb-ar^tm7.1Mkg
• Gene: Rr320 Location: Chr7:103501973-103526752 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Rr320^tm7.1Mkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183764
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The DNAse I hypersensitivity sites HS2 and HS3 were replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. (J:183764)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr320 Mutation: 0 strains or lines available

References

• Original: J:183764 Bender MA, et al., The hypersensitive sites of the murine beta-globin locus control region act independently to affect nuclear localization and transcriptional elongation. Blood. 2012 Apr 19;119(16):3820-7
• All: 1 reference(s)