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Il17rbtm1Hwata
Targeted Allele Detail
Summary
Symbol: Il17rbtm1Hwata
Name: interleukin 17 receptor B; targeted mutation 1, Hiroshi Watarai
MGI ID: MGI:5426267
Gene: Il17rb  Location: Chr14:29718125-29730853 bp, - strand  Genetic Position: Chr14, 18.39 cM
Alliance: Il17rbtm1Hwata page
Il17rbtm1Hwata/Il17rbtm1Hwata and Tcra-Jtm1Tgi/Tcra-Jtm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184570
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced the coding sequence in exon 1 and all of exon 2. Flow cytometry confirmed the absence of protein expression in the iNKT cells of the spleen. (J:184570)
Generation of the Il17rbtm1Hwata allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il17rb Mutation:  27 strains or lines available
References
Original:  J:184570 Watarai H, et al., Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biol. 2012 Feb;10(2):e1001255
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory