Rapgef3^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1Geno
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1, Genoway
• MGI ID: MGI:5425762
• Synonyms: EPAC1^fs+/+
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182701
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of exon 3, followed by an frt-flanked neomycin cassette, and a second loxP site downstream of exon 6. The vector contained a 6.3 kb long homology arm and a 1.6 kb short homology arm. (J:182701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 45 strains or lines available

References

• Original: J:182701 Yang Y, et al., EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 2012 Feb 23;73(4):774-88
• All: 14 reference(s)