Hoxb4^tm2.1Karl
Targeted Allele Detail

Summary

• Symbol: Hoxb4^tm2.1Karl
• Name: homeobox B4; targeted mutation 2.1, Stefan Karlsson
• MGI ID: MGI:5320448
• Gene: Hoxb4 Location: Chr11:96209093-96212464 bp, + strand Genetic Position: Chr11, 59.83 cM
• Alliance: Hoxb4^tm2.1Karl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83563
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistance cassette (neo) was introduced 5' of the transcription initiation site of Hoxb4 and was subsequently deleted by transient Cre expression, leaving a single loxP site upstream of Hoxb4. Presence of the loxP site does not affect expression of the gene. (J:83563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxb4 Mutation: 18 strains or lines available

References

• Original: J:83563 Bjornsson JM, et al., Reduced proliferative capacity of hematopoietic stem cells deficient in hoxb3 and hoxb4. Mol Cell Biol. 2003 Jun;23(11):3872-83
• All: 1 reference(s)