Hprt1^{tm86(NR2E1,bEMS223)Ems}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm86(NR2E1,bEMS223)Ems}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 86, Elizabeth M Simpson
• MGI ID: MGI:5319310
• Synonyms: Hprt^{tm86(bEMS223)Ems}, Hprt^{tm86(NR2E1)Ems}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm86(NR2E1,bEMS223)Ems} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183689
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm86(NR2E1,bEMS223)Ems} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NR2E1 (7101)

  Nr2e1

  (MGI:1100526)

• Mutation details: bEMS223 is a modification of the human BAC RP11-144P8, which contains the whole (NR2E1) gene, to target a single copy into the locus. (J:183689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

Notes

Parent cell line = mEMS2044

References

• Original: J:183689 Schmouth JF, et al., Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice. Mol Cell Biol. 2012 Apr;32(7):1296-311
• All: 2 reference(s)