Tg(Ins1-Akt*)138Perm
Transgene Detail

Summary

• Symbol: Tg(Ins1-Akt*)138Perm
• Name: transgene insertion 138, M Permutt
• MGI ID: MGI:5318861
• Synonyms: caAkt^Tg, RIP-Akt
• Transgene: Tg(Ins1-Akt*)138Perm Location: unknown
• Alliance: Tg(Ins1-Akt*)138Perm page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene expressesa constitutively active Akt1 that lacks the PH domain (Aktdelta4-129) and contains an N-terminal Src myristolation signal (myrAktdelta4-129) along with an hemagglutinin (HA) tag for monitoring expression from the rat insulin 1 promoter. Three transgenic founders (no. 167, no. 138, and no. 139) were established. (J:73141)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73141 Bernal-Mizrachi E, et al., Islet beta cell expression of constitutively active Akt1/PKBalpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest. 2001 Dec;108(11):1631-8
• All: 5 reference(s)