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Pum1tm1.2Hfl
Targeted Allele Detail
Summary
Symbol: Pum1tm1.2Hfl
Name: pumilio RNA-binding family member 1; targeted mutation 1.1, Haifan Lin
MGI ID: MGI:5316377
Gene: Pum1  Location: Chr4:130390632-130508875 bp, + strand  Genetic Position: Chr4, 63.43 cM
Alliance: Pum1tm1.2Hfl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182280
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exons 8 and 9 along with the neo cassette. Western blot analysis confirmed the absence of protein expression in the testes. (J:182280)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pum1 Mutation:  169 strains or lines available
References
Original:  J:182280 Chen D, et al., Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Curr Biol. 2012 Mar 6;22(5):420-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory