Commd1^tm2.1Bvds
Targeted Allele Detail

Summary

• Symbol: Commd1^tm2.1Bvds
• Name: COMM domain containing 1; targeted mutation 2.1, Bart van de Sluis
• MGI ID: MGI:5315712
• Synonyms: Commd1^loxP, Commd1P^loxP
• Gene: Commd1 Location: Chr11:22849728-22934539 bp, - strand Genetic Position: Chr11, 14.22 cM
• Alliance: Commd1^tm2.1Bvds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT- and loxP- flanked neo cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:182331)

Generation of the conditional Commd1^tm2.1Bvds allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Commd1 Mutation: 31 strains or lines available

References

• Original: J:182331 Vonk WI, et al., Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation. PLoS One. 2011;6(12):e29183
• All: 10 reference(s)