Tg(Slc17a6-COP4*H134R/EYFP)2Oki
Transgene Detail

Summary

• Symbol: Tg(Slc17a6-COP4*H134R/EYFP)2Oki
• Name: transgene insertion 2, Ole Kiehn
• MGI ID: MGI:5314662
• Synonyms: Vglut2-ChR2-YFP, vGluT2-YFP
• Transgene: Tg(Slc17a6-COP4*H134R/EYFP)2Oki Location: unknown
• Alliance: Tg(Slc17a6-COP4*H134R/EYFP)2Oki page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: A bacterial articificial chromosone (BAC) # RPCI23-84M15 containing the mouse Vglut2 gene was modified by the introduction of a human codon-optimized channel rhodopsin (hChR2) and a gain-of-function H134R substitution fused to an enhanced yellow fluorescent protein sequence (EYFP) and inserted to inactivate the Vglut2 gene. Line 2 was generated. (J:180947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:180947 Hagglund M, et al., Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion. Nat Neurosci. 2010 Feb;13(2):246-52
• All: 6 reference(s)