Hprt1^{tm2(CAG-TBX2,-EGFP)Akis}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm2(CAG-TBX2,-EGFP)Akis}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Andreas Kispert
• MGI ID: MGI:5314539
• Synonyms: HpCT2
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm2(CAG-TBX2,-EGFP)Akis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181526
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Hprt1^{tm2(CAG-TBX2,-EGFP)Akis} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TBX2 (6909)

  Tbx2	(MGI:98494)

• Mutation details: Exon 1 was replaced with a CAG promoter, loxP site, neo/stop cassette, loxP2272 site, inverted human TBX2 cDNA, IRES and EGFP cassette, loxP site, and loxP2272 site. Cre-mediated recombination is required to achieve expression of TBX2 and EGFP. (J:181526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:181526 Singh R, et al., Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci. 2012 Apr;69(8):1377-89
• All: 8 reference(s)